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Lom (HMSNL) is a rare autosomal-recessive demyelinating neuropathy that was initially recognized in Bulgarian gypsies from the town of Lom109,164 ; however, not all affected people are of gypsy ancestry165 Individuals who are affected develop distal leg weakness in the rst decade of life, which progresses to involve the hands by the second decade of life Subsequently, hearing loss is generally noted in the third decade Reduced sensation to all modalities and hypore exia are appreciated on examination Pes cavus, hammer toes, clawing of the hands, and scoliosis are also common

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NCS reveal a demyelinating sensorimotor polyneuropathy109,164 Sensory studies are generally unobtainable, but when SNAPs are present, the distal latencies are prolonged and the NCVs are slow Motor NCS are remarkable for markedly prolonged distal latencies and slow NCVs (ranging from 9 to 20 m/s) in the arms and legs Active denervation changes are appreciated on needle EMG Brainstem auditory-evoked potentials reveal both peripheral and central slowing of auditory conduction Subcortical white matter abnormalities may be appreciated on magnetic resonance imaging of the brain165 NCS reveal features of both demyelination and axonal degeneration, which are more severe in men compared to women2,10,166,167,169,170,174 177 SNAPs are reduced in amplitude or absent in the majority of patients but, when obtainable, the distal latencies are prolonged and CVs are slow Peroneal CMAPs are absent in as many as two-thirds of patients, while median and ulnar CMAPs are often reduced in amplitude167,169 Distal motor latencies are prolonged in men more than in women with CMT1X167 In men, motor NCVs in the arms and legs are moderately slow (median nerve 31 +/ 6 m/s; peroneal nerve 310 +/ 39 m/s)169 These NCVs in men with CMT1X are approximately 10 m/s faster than that usually seen in autosomal-dominant forms of CMT1 In contrast, motor NCVs in women with CMT1X may be only slightly slow (median nerve 446 +/ 88 m/s; peroneal nerve 338 +/ 81 m/s)169 As previously discussed, uniform slowing of motor NCVs is the rule in CMT1 and helps distinguish hereditary from acquired forms of demyelinating polyneuropathy15 However, nonuniform slowing

The monomelic polyneuropathies are relatively uncommon disorders that typically result from acute limb ischemia Occlusion of major limb vessels such as the aortic bifurcation, external iliac, or super cial femoral artery resulting from embolus or instrumentation such as intra-aortic balloon pumping or arterial cannulation associated with coronary bypass grafting are the typical causes in the lower extremities10,70,167,168 Implicit in the description of this syndrome is the belief that nerve is either more readily injured or less readily recoverable with acute limb ischemia than are other limb tissues Chronic limb ischemia has been reported to associate with electrodiagnostic ndings, suggesting lengthdependent axon loss169 172 Whether this ever translates into a clinically evident neuropathy in the absence of other tissue damage is a matter of controversy Most disorders that affect multiple nerves or multiple nerve roots are systemic disorders that typically affect more than one extremity Monomelic polyneuropathies bear resemblance to plexopathies in that both

Emulator debugging is performed through the debugging view of Carbidec++ Starting a debugging session for a project will automatically launch the target application within the emulator and attach to the emulator process The debugging view provides several additional frames to the user interface The top left lists the threads running within the emulator, and the top right lists the watch variables, current breakpoints, and SymbianOS-specific data To create a new breakpoint, double-click on the margin of the line of source code where you would like to explore the program flow control At this point, variables can be examined to determine whether they contain the expected value If they do, step over, step out, and step into functionality is supported This allows the developer the flexibility to only delve into the functions they are interested in

Step 3 Unlike earlier versions of Windows, which included icons for My Computer and My Documents on the desktop by default, in Windows XP the only icon present on the desktop after installation is the Recycle Bin These icons are now in the Start menu, but you can add them to the desktop: a) Click the Start button b) Right-click My Computer in the menu c) Select Show on Desktop d) Repeat Steps a) through c) for My Documents Step 4 For greatest compatibility with the lab exercises in upcoming chapters, you should now put your Start menu in the Classic Start menu mode To set the Start menu to Classic mode, follow these steps: a) Right-click the Start button b) Select Properties c) Choose Classic Start menu d) Click OK

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